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I haven't tied large inline spinners but I have tied a lot of streamers of various sizes. I find it doesn't move like bucktail, goat or similar. I usually use it in combo with other hairs. I would guess the run depth would be more related to weight of the spinner and not the hair. I have never had an issue tying it down. I just secure it and use head cement or nail polish on the thread. I haven't used it for pike or muskie but don't know why it wouldn't work. Hope it helps.