You would have an incredibly difficult time replicating the hollow chambers if your factory made jerkbaits without going the ABS route with a substantial investment into special machinery.
You could make a "shell" inside your mold with some slow setting resin place your weight with bb's or whatever ballast you choose, then back-fill with something buoyant like a 2 part foam. But as mentioned above, it isn't easy.
The easiest route is to make your buoyant resin baits and add ballast after curing to get the right placement and amount. My process involves having lead plugs made from various size drill bits i use for my ballast holes. 1/4" half depth, 1/4" full depth, 1/4" 1.5 depth and so on all the way up to my largest size which is 3/8" 1.5 depth. I use forstner bits for these holes so 1.5 depth means 1 and a half times the depth of the head on the bit in case that wasn't clear. You could do this same thing with tape and standard bits. Then hot glue your plugs in different positions on the bottom of the bait until you achieve your desired sink rate and balance.
Just my $0.02. Good luck with your builds!